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Several technical reasons may explain our distinctive findings, including differences in the microbiome sampling site, the limited n per group, singly housing mice, or the use of highly similar lean, Western, and high-fat diets which systematically exchanged fat content with carbohydrate content

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This combination activates lethal autophagy dependent on AMPK activation (AMPK kinase is activated by a decrease in intracellular ATP and a change in the ATP:AMP ratio), enhancing the sensitivity of radiation-resistant cells to cell death and efficacy of radiotherapy 29,77 (Figure 3)

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